Trimethylchlorosilane (TMCS) is a colorless, volatile liquid with the formula (CH₃)₃SiCl, widely used as a silylating agent in organic synthesis and silicone production. It introduces trimethylsilyl (TMS) groups to protect hydroxyl, amino, and carboxyl groups, making molecules more volatile and less reactive. In the silicone industry, TMCS serves as a precursor for silicone oils, sealants, and resins by capping silanol groups to enhance stability.
< Pharmaceutical APIs
It is also instrumental in pharmaceutical and analytical chemistry, facilitating derivatization for gas chromatography (GC) analysis. Additionally, TMCS is used as a raw material for API such as Dapagliflozin along with Triethylsilane. It is used to make also used to make HMDS – Hexamethyldisilazane & HMDSO – Hexamethyldisiloxane
TMCS is used for creating hydrophobic coatings on glass, textiles, and electronics, making it a versatile compound across various industries.
Trimethylchlorosilane (TMCS) acts as a silane coupling agent by forming a molecular bridge between organic polymers and inorganic surfaces like glass, metal, or silica.Widely used in fiberglass composites, paints, sealants, and adhesives to enhance adhesion and water resistance.
| Parameters | Specifications |
|---|---|
| Appearance | A Clear Colourless Liquid. |
| Solubility | Insoluble in water & miscible in Acetone |
| Specific gravity | Between 0.851 to 0.861 |
| Boiling Range | 55 °C to 59 °C |
| HMDO (by GC) | NMT 0.50 % |
| Purity as TMCS | NLT 99.00% |