1,1,1,3,3,3-Hexamethyldisilazane (HMDS) is a key organosilicon compound used in pharmaceuticals, semiconductors, and polymers. In pharma, it aids in API synthesis, acting as a silylating agent and mild base for functional group protection. In the semiconductor industry, it enhances photoresist adhesion on silicon wafers. It also hydrophobizes surfaces in coatings and polymers. Additionally, HMDS is a crucial intermediate in siloxane polymer production for sealants and lubricants.
Pharmaceuticals APIs >
1,1,1,3,3,3-Hexamethyldisilazane (HMDS) is used in the pharmaceutical industry as a key intermediate for manufacturing several Active Pharmaceutical Ingredients (APIs), including Gemcitabine, Cefprozil, Cefadroxil, Sofosbuvir, Lamivudine, Acyclovir, Ampicillin, Azacitadine, Ganciclovir, Mecillinam, Tegafur, and Trifluridine.
Adhesives & Sealants >
HMDS is crucial for siloxane polymer production, where it reacts with moisture or acidic catalysts to create siloxane-based materials. These materials provide water resistance, durability, and adhesion in sealants. In lubricants, HMDS-derived silicone oils offer benefits such as low surface tension, thermal stability, and chemical inertness, making them suitable for high-performance applications. Additionally, HMDS is used for surface treatment, providing a non-stick, anti-corrosive coating that improves lubrication efficiency and extends the lifespan of products.
Photolithography >
Hexamethyldisilazane (HMDS) is widely used in the photolithography process as an adhesion promoter to enhance the bonding between the photoresist and the silicon wafer. HMDS can be applied using vapor priming or spin coating methods to create a uniform adhesion layer before photoresist deposition.
| Parameter | Specifications |
|---|---|
| Appearance | A Clear Colorless Liquid. |
| Solubility | Insoluble in water & miscible in Acetone |
| Identification | RT of the major peak in the chromatogram of the sample solution should correspond to that of the standard solution as obtained in chromatographic purity (By GC). |
| Specific gravity(@ 25oC) | NMT 0.78 gml |
| Boiling Range | 123 oC to 127 oC |
| HMDO (by GC) | NMT 0.50 % |
| Chromatography purity (By GC.) | NLT 99.00 % |